Figure 3From: Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord P38 phosphorylation following MIA injection. P38 phosphorylation was increased in both ipsilateral and contralateral dorsal horn spinal cord at 1, 2 and 3 wk following MIA as compared to naïve control rats (A). Phospho-p38 immunoreactivity (black stained cells) was observed throughout the upper lamina (hatched box) of the dorsal horn (B) that reached maximal levels at 1-wk and declined thereafter as compared to naive (non-pain) controls (ANOVA: F = 9.686, p < 0.0001). All data are represented as mean values (± S.E.M) of the percent of ipsilateral naïve control rats; * p < 0.05, ** p < 0.01 vs. naïve controls (Fisher's PLSD post hoc analysis); n = 5-7/group.Back to article page