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Figure 3 | Molecular Pain

Figure 3

From: Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord

Figure 3

P38 phosphorylation following MIA injection. P38 phosphorylation was increased in both ipsilateral and contralateral dorsal horn spinal cord at 1, 2 and 3 wk following MIA as compared to naïve control rats (A). Phospho-p38 immunoreactivity (black stained cells) was observed throughout the upper lamina (hatched box) of the dorsal horn (B) that reached maximal levels at 1-wk and declined thereafter as compared to naive (non-pain) controls (ANOVA: F = 9.686, p < 0.0001). All data are represented as mean values (± S.E.M) of the percent of ipsilateral naïve control rats; * p < 0.05, ** p < 0.01 vs. naïve controls (Fisher's PLSD post hoc analysis); n = 5-7/group.

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