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Figure 7 | Molecular Pain

Figure 7

From: Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord

Figure 7

Effects of MEK (ERK kinase) inhibitor PD98059 on pERK1/2 immunoreactivity in spinal dorsal horns. Intrathecal administration of PD98059 (10 μg) 30-min before nociceptive behavior assessment attenuated the MIA-induced reduction of grip force strength in 3-wk MIA rats (A). Grip force strength was expressed as CFmax/kg body weight; *p < 0.05, **p < 0.01 vs. naïve controls, # p < 0.05 vs. vehicle alone treated MIA rat; n = 6/group. MIA-OA vehicle-i.t. controls rats displayed a significant increase in spinal pERK1/2 when immunohistochemically processed immediately following grip force testing, whereas PD98059-treated MIA-OA rats did not exhibit the same significant increase (B). ERK phosphorylation data are represented as mean values (± S.E.M) of the percent of ipsilateral naïve control rats; ** p < 0.01 vs. naïve controls (Fisher's PLSD post hoc analysis); n = 6/group.

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Molecular Pain

ISSN: 1744-8069

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