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Figure 2 | Molecular Pain

Figure 2

From: Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin

Figure 2

A short-term treatment of artemin decreased AITC-induced currents in DRG neurons. (A, B): Representative traces show TRPA1 currents produced by repeated AITC application without (A) or with (B) artemin (100 ng/ml) treatment. AITC was re-applied after artemin administration for 2 min. (C): Bar graph shows the effect of artemin on AITC activated currents. Currents were normalized to the values evoked initially by AITC application in the absence of artemin. Numbers in parenthesis indicate cells tested. (D): Representative traces show time-course of TRPA1 currents induced by repeated AITC application after artemin (100 ng/ml) treatment. AITC (300 μM) in a bath solution was perfused for 20s in all experiments.

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