Figure 6
From: Central nervous system mast cells in peripheral inflammatory nociception
Effect of intrathecally administered mast cell inhibitors on carrageenan hyperalgesia and mast cell degranulation and density. Intrathecal administration of either cromolyn or BAY-613606 in female rats before and after carrageenan (at timepoints shown by ↑) does not inhibit mechanical hyperalgesia (A), thermal hyperalgesia (B), or cold allodynia (C). However, BAY-613606 significantly reduces the percent mast cell degranulation in lumbar dura mater (D) (** = P < 0.001) but not in the thoracic dura mater (E) of female rats, while both cromolyn and BAY-613606 inhibit the increased degranulated mast cell density induced by carrageenan in female rats in the lumbar dura mater (F) (* = P < 0.05) but not in the thoracic dura mater (G).