Figure 1

Examples of nociceptive RT units in a WT (A) and a Cav3.2 KO (B) mice. Rate histograms show the unit activity changes during innocuous and noxious stimulations (bin = 1 s). The horizontal bars indicate periods for the air puff, brush, light touch and pinch stimulations, respectively, applied to the center of the receptive field of the units, both in the contralateral forepaw. Pinch stimuli repeated twice with the same vessel clamp. Nociceptive units responded to pinching consistently. Light touch units did not respond to pinching. Note both units were inhibited in the beginning of the pinch and followed by excitation and long afterdischages. Red horizontal lines are 95% confidence interval calculated from basal activity. Time scales are 50 s.