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Figure 3 | Molecular Pain

Figure 3

From: Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root

Figure 3

The antinociceptive effects of Ro25-6981 in rats with compression of the trigeminal nerve root. The effects of Ro25-6981, a selective NR2B antagonist, on mechanical allodynia (A, B) and hyperalgesia (C, D) in rats with compression of the trigeminal root (n = 8 in each treatment group). Neither the intracisternal administration of vehicle nor 50 or 100 μg of Ro25-6981 affected the air-puff thresholds on both the ipsilateral (A) and contralateral (B) sides. Moreover, injections of 50 or 100 μg of Ro25-6981 did not affect pin-prick scores on either side (C, D).

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Molecular Pain

ISSN: 1744-8069

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