Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root

Table 1 Effects of the intracisternal administration of NR antagonists on motor functions

Post injection time		30 min	1 hr	2 hr	3 hr	5 hr
Chemicals	Dose (μg)	The time of motor performance (min)
AP5	10	60 ± 30*	180	180	180	180
	20	4 ± 2*	94 ± 36*	162 ± 28	180	180
PPPA	1	180	180	180	180	180
	10	2 ± 1*	2 ± 1*	2 ± 1*	5 ± 2*	70 ± 39*
PPDA	5	32 ± 14*	81 ± 28*	180	180	180
	10	4 ± 2*	5 ± 3*	30 ± 17*	57 ± 16*	180

The time course of motor performance (min) was evaluated using a rotarod test following the injection of NR2 antagonists. The time course of motor performance prior to treatment and the cut-off time is 180 min. Neither intracisternal administration of vehicle nor Ro25-6981, a selective NR2B antagonist, altered the time course of motor performance. There were 6 animals in each treatment group. * P < 0.05, compared with the vehicle-treated group.

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