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Table 1 Effects of the intracisternal administration of NR antagonists on motor functions

From: Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root

Post injection time 30 min 1 hr 2 hr 3 hr 5 hr
Chemicals Dose (μg) The time of motor performance (min)
AP5 10 60 ± 30* 180 180 180 180
  20 4 ± 2* 94 ± 36* 162 ± 28 180 180
PPPA 1 180 180 180 180 180
  10 2 ± 1* 2 ± 1* 2 ± 1* 5 ± 2* 70 ± 39*
PPDA 5 32 ± 14* 81 ± 28* 180 180 180
  10 4 ± 2* 5 ± 3* 30 ± 17* 57 ± 16* 180
  1. The time course of motor performance (min) was evaluated using a rotarod test following the injection of NR2 antagonists. The time course of motor performance prior to treatment and the cut-off time is 180 min. Neither intracisternal administration of vehicle nor Ro25-6981, a selective NR2B antagonist, altered the time course of motor performance. There were 6 animals in each treatment group. * P < 0.05, compared with the vehicle-treated group.