Figure 2
From: Resveratrol inhibits Cdk5 activity through regulation of p35 expression
Resveratrol inhibits p35 promoter activity. A) Resveratrol treatment for 24 hr at different concentrations decreased p35 promoter activity in a dose-dependent manner in stable clone C7 cells. B) Cell viability was unchanged in up to 25 μM of resveratrol, but at 50 μM and 100 μM it was reduced significantly in comparison to the control. C) Resveratrol treatment (10 μM) decreased p35 promoter activity in a time-dependent manner. D) Stable clone C7 cells were treated with TNF-α (50 ng/ml), resveratrol (25 μM), and TNF-α (50 ng/ml) plus resveratrol (25 μM) during 24 h and p35 promoter activity was measured. Resveratrol blocked the TNF-α mediated increase in p35 expression. All data are presented as the mean and SEM (n = 4). *p <0.05, ***p < 0.0001 (Bonferroni test after ANOVA).