Figure 7
From: Resveratrol inhibits Cdk5 activity through regulation of p35 expression
Proposed resveratrol-mediated regulation of p35 expression and Cdk5 activity. Resveratrol (RESV) reduces Cdk5 activity through inhibition of p35 expression. The inhibitory effects of resveratrol on p35 expression could be brought about at several levels, inhibition of ERK1/2 signaling pathway could affect Egr-1 expression, or activation of the p38 MAPK, JNK and NF-κB signaling pathways could downregulate p35 promoter activity.