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Figure 4 | Molecular Pain

Figure 4

From: Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Figure 4

Pharmacological inhibition of NOS/NO suppressed tactile allodynia after spinal nerve injury. (A, B) Effect of L-NAME, a non-selective NOS inhibitor. PWTs (A; ipsilateral hindpaw, B; contralateral hindpaw) following intraperitoneal administration of L-NAME to rats once daily before (0) and 1, 3, 5 and 7 days after fifth lumbar spinal nerve injury (n = 6 animals/group). (C) Effect of intraperitoneal (i.p.) administration of L-NAME on the decrease in PWTs after 7 days of spinal nerve injury (n = 4 animals/group). (D) Effect of intraperitoneal (i.t.) administration of 7-nitroindazole (7-NI), a selective nNOS inhibitor, on the decrease in PWTs after 7 days of spinal nerve injury (n = 4 animals/group). All data are presented as a mean ± SEM. Statistical analysis were determined by one-way repeated ANOVA (C) or two-way repeated ANOVA (A, B, D) with Tukey's test, *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle treatment, ###P < 0.001 vs. pre measurement.

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Molecular Pain

ISSN: 1744-8069

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