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Figure 5 | Molecular Pain

Figure 5

From: Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Figure 5

Increased expression of iNOS, nNOS and Mac-1 mRNA in microglial cell line cultures. Expression levels of iNOS (A) and nNOS (B) mRNA in MG-5 microglial cell line cultures. These mRNA expression levels significantly increased following treatment with interferon-γ (IFN-γ) in a dose-dependent manor (n = 6 samples/group). In addition, (C) the expression levels of Mac-1 mRNA were significantly increased following IFN-γ exposure. This increase was attenuated by co-treatment with L-NAME (n = 6 samples/group). All data are presented as a mean ± SEM. Statistical analysis was determined by one-way ANOVA with Tukey's test, *P < 0.05, **P < 0.01, ***P < 0.001.

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