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Figure 6 | Molecular Pain

Figure 6

From: Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases

Figure 6

Microglial activation, and increased IL-6, TLR4 and P2X4 receptor mRNA expression levels via NO. Expression levels of Mac-1 (A), interleukin-6 (IL-6; B), toll-like receptor 4 (TLR4; C) and P2X4 receptor (P2X4R; D) mRNA in MG-5 microglial cell line cultures. mRNA expression levels were significant increased by treatment with sodium nitroprusside (SNP), a NO donor (n = 6 samples/group). All data are presented as a mean ± SEM. Statistical analysis was determined by one-way ANOVA with Tukey's test, *P < 0.05, **P < 0.01, ***P < 0.001.

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