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Figure 1 | Molecular Pain

Figure 1

From: Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats

Figure 1

Effect of rhEPO on cytokine expression and behavioral activities. Control tests were performed to evaluate whether rhEPO injection affect inflammatory cytokine expression in neonatal rats or behavior in juvenile rats. A - C: The mRNA levels of IL-6, TNF-α and IL-1β in the somatosensory cortex 12 hrs after a single injection of rhEPO (5000 U/kg) in P3 neonatal rats. D - F: The mRNA levels of IL-6, TNF-α and IL-1β in the somatosensory cortex on postnatal day 21 after 3 injection sessions of rhEPO (5000 U/kg) in P3-P5 neonatal rats. G - I: rhEPO did not influence the behavior of juvenile rats that were injected three times with rhEPO at P3, P4 and P5. Saline injected controls and rhEPO injected animals performed similarly in the defensive-withdrawal (G), hot-plate (H) and the Rota-rod (I) tests (n = 4 for each group).

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Molecular Pain

ISSN: 1744-8069

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