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Figure 2 | Molecular Pain

Figure 2

From: Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats

Figure 2

Effect of rhEPO on inflammatory pain-induced cell death. rhEPO reduced cell death in the cortex, hypothalamus and hippocampus after 3 formalin injection sessions (72 hrs). A - F: Immunofluorescent images of TUNEL-positive cells (arrow) in the cortex (A and B) and the hypothalamus (C and D). E and F are magnified selected areas in C and D, respectively. The inset in E is a further enlarged (40×) image of the selected area (Blue: Hoechst, green: TUNEL). G - I: Immunofluorescent images of fluoro-Jade C positive neurons (arrowheads) in the hippocampus after 3 repetitive saline (G), formalin (H) or formalin plus rhEPO injection (I) sessions (green: FJC-positive cell). Bar = 100 μm for A to D, 50 μm for E and F, and 100 μm for G to I.

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Molecular Pain

ISSN: 1744-8069

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