Figure 4From: Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats Effects of rhEPO on expression of inflammatory factors. Real time PCR measurements of inflammatory factors in somatosensory cortex or DRG from control and experimental rats. A - D: The mRNA levels of IL-1β in the somatosensory cortex 4 and 12 hrs after a single injection or after 3 injection sessions (72 hrs and P21) of saline, formalin or formalin plus rhEPO groups. E - H: The mRNA levels of IL-6 in the somatosensory cortex 4 and 12 hrs after a single injection or after 3 injection sessions (72 hrs and P21) of saline, formalin or formalin plus rhEPO groups. I - L: TNF-α mRNA levels in the somatosensory cortex 4 and 12 hrs after a single injection or after 3 injection sessions (72 hrs and P21). M and N: The mRNA levels of CGRP (J) and substance P (SP) in DRG neurons 12 hrs after a single injection. All results are expressed as fold changes compared to the control. 18S rRNA was used as an internal control. n = 6 in each group; *. p < 0.05 compared to saline group; #. p < 0.05 compared to formalin group.Back to article page