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Figure 4 | Molecular Pain

Figure 4

From: Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats

Figure 4

Effects of rhEPO on expression of inflammatory factors. Real time PCR measurements of inflammatory factors in somatosensory cortex or DRG from control and experimental rats. A - D: The mRNA levels of IL-1β in the somatosensory cortex 4 and 12 hrs after a single injection or after 3 injection sessions (72 hrs and P21) of saline, formalin or formalin plus rhEPO groups. E - H: The mRNA levels of IL-6 in the somatosensory cortex 4 and 12 hrs after a single injection or after 3 injection sessions (72 hrs and P21) of saline, formalin or formalin plus rhEPO groups. I - L: TNF-α mRNA levels in the somatosensory cortex 4 and 12 hrs after a single injection or after 3 injection sessions (72 hrs and P21). M and N: The mRNA levels of CGRP (J) and substance P (SP) in DRG neurons 12 hrs after a single injection. All results are expressed as fold changes compared to the control. 18S rRNA was used as an internal control. n = 6 in each group; *. p < 0.05 compared to saline group; #. p < 0.05 compared to formalin group.

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