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Figure 5 | Molecular Pain

Figure 5

From: Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats

Figure 5

Effect of rhEPO on pain sensitivity and cerebral blood flow of formalin-injected rats. Rats were subjected to pain sensitivity hot plate and tail flick tests and cerebral blood flow was measured using a laser Doppler scanner. A and B: Measurements of pain latencies on hot-plate (A) and tail-flick (B) tests in 21 day old juvenile rats after different treatments during infancy (P3 to P5). rhEPO restores normal pain sensitivity after formalin injections. C: Representative laser Doppler graphs of blood flow levels in the right somatosensory cortex of P5 rats after the third injection of formalin or formalin plus rhEPO. The calibration bar on the right shows relative levels of flow. D and E: The ratio of blood flow after/before injections from experiments in C, in the right (D) and left (E) hemispheres. The values are averaged from five consecutive readings. N = 7 in pain tests and n = 6 in blood flow measurements; *. p < 0.05 compared to saline group; #. p < 0.05 compared to formalin group.

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