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Figure 4 | Molecular Pain

Figure 4

From: Cortical plasticity as a new endpoint measurement for chronic pain

Figure 4

Increased synaptic transmission in layer II/III in the ACC after peripheral nerve ligation. A, Synaptic input-output curves in slices from control (n = 6 neurons) and nerve-ligated (n = 7 neurons) mice. *p < 0.05 and **p < 0.01 compared with those of control group. Open circles, Neurons from control mice; filled circles, neurons from mice with nerve ligation. B, Representative traces with an interval of 50 ms recorded in layer II/III of the ACC. Paired-pulse ratio (the ratio of EPSC2/EPSC1) was recorded at intervals of 35, 50, 75, 100, and 150 ms from control and nerve-ligated mice. Open circles, Neurons from control mice (n = 17 neurons); filled circles, neurons from mice with nerve ligation (n = 19 neurons). *p < 0.05; **p < 0.01; ***p < 0.001. C, PPF in layer V of the ACC from control and nerve-ligated mice. Open circles, Neurons from control mice (n = 9 neurons); filled circles, neurons from mice with nerve ligation (n = 15 neurons). D, PPF in motor cortex neurons from control and nerve-ligated mice. Open circles, Neurons from control mice (n = 5 neurons); filled circles, neurons from mice with nerve ligation (n = 5 neurons) (from reference 31).

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