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Figure 7 | Molecular Pain

Figure 7

From: Cortical plasticity as a new endpoint measurement for chronic pain

Figure 7

Expression and phosphorylation of PKMζ in the ACC during neuropathic pain. A, Mechanical allodynia was tested in the sham and nerve injury groups from wild-type (WT) and AC1-/- animals 3 days after nerve injury. * indicates P < 0.05; error bars indicate SEMs. B, Western blots for PKMζ and p-PKMζ in the ACC obtained between 3 days and 2 weeks after nerve injury. (The ACC of mice from the sham and nerve injury groups were used for Western blot analysis 90 min after the allodynia test.) C, Level of PKMζ in the ACC of mice from the sham and nerve injury groups. Level of PKMζ increased significantly 3 days after nerve injury compared with PKMζ in the sham group. D, Level of p-PKMζ increased significantly 3 days after nerve injury. This effect lasted over 2 weeks after nerve injury compared with p-PKMζ in the sham group (from Reference 32).

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