Figure 2

Effect of TC-2559 on formalin-induced biphasic nociceptive responses in mice. A, Traces showing intraperitoneal injection of TC-2559 (1, 3, 10 mg/kg) dose dependently suppressed formalin induced progressive biphasic pain behavior score; B, Bar histogram showing the group data of antinociceptive effect of TC-2559 on formalin induced paw lift-licking time in both early 1st phase (0-5 min) and late 2nd phase (5-30 min) of mice formalin model. *P < 0.05, **P < 0.01 compared with vehicle saline control (two-way ANOVA followed by the Holm-Sidak test).