Figure 1
From: Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas
Expression of Nav and Kv7.2 channels in nodes of Ranvier of intact fibres. A and B show teased fibers form normal saphenous nerves immunostained for Myelin P2 and Pan Nav (A) or Kv7.2 (B). In this and following figures, color codes for antibodies are specified on images. Note that the fibers are well structured and nodes are easily identifiable. The following figures show high magnification images of nodal Nav channels flanked by depositions of Myelin P2 (C 1 ), Caspr (D), Pan NF (E). C 2 shows the profile of immunofluorescence intensity along the nodal/paranodal zone shown in C 1 (in this and following figures intensity curves are given in arbitrary units). F and G show nodal zones costained for Kv7.2 and Myelin P2 (F 1 ) or Caspr (G). F 2 shows the profile of immunofluorescence intensity along the nodal/paranodal zone shown in F 1 . Scale bars: for A and B, 20 μm (shown in B); for C 1 , D, F 1 and G, 5 μm (shown in G); for E, 5 μm.