Nociceptive response of PrP+/+ and PrP-/- mice under neuropathic pain conditions. Mechanical (panel A) and thermal (panel B) withdrawal threshold of wild type or PrPc null mice after CCI-induced neuropathy. The control data were obtained from sham-operated animals. (C) Effect of pretreatment of animals with MK-801 (3 nmol/i.t.) on mechanical withdrawal threshold. Each point or column represents the mean ± S.E.M. (n = 6-12). *P < 0.05, **P < 0.01, ***P < 0.001.