P2XR antagonists significantly reduce STZ-induced mechanical allodynia. The effects of the subcutaneously administrated P2XR antagonists (A) PPADS and (B) TNP-ATP on PWTs were studied in rats two weeks after a STZ injection. The PWTs measured in the presence of antagonists were significantly larger than those measured in PBS. Thus, the P2XR antagonists partially reversed the mechanical allodynia induced by the STZ treatment. (*P < 0.05, n = 8-10).