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Table 1 Effects of ACC lesions on the anti-nociceptive effects of EA in rats with formalin injection

From: Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats

  Paw lifting time (s) Paw licking time (s)
  Phase 1 Phase 2 Phase 1 Phase 2
Formalin to left paws     
   Sham lesion 66.3 ± 13.9 595.5 ± 80.0 61.3 ± 12.2 440.1 ± 44.7
   Sham lesion + ipsi-EA 45.8 ± 8.0 282.7 ± 28.7 *** 56.1 ± 6.3 378.3 ± 48.2
   Sham lesion + contra-EA 65.3 ± 10.5 369.7 ± 59.8 ** 47.0 ± 9.1 231.3 ± 30.6 ***
   ACC lesion 63.1 ± 8.1 623.6 ± 80.9 45.0 ± 8.2 362.6 ± 60.9
   ACC lesion + ipsi-EA 42.3 ± 6.4 401.7 ± 53.1 ** 53.0 ± 5.4 357.9 ± 56.8
   ACC lesion + contra-EA 57.3 ± 3.2 496.9 ± 68.2 68.5 ± 9.2 358.8 ± 36.0#
Formalin to right paws     
   Sham lesion 115.6 ± 19.2 815.5 ± 104.4 61.5 ± 4.7 269.6 ± 48.4
   Sham lesion + ipsi-EA 81.0 ± 11.9 365.1 ± 50.9 *** 63.0 ± 7.2 249.1 ± 42.7
   Sham lesion + contra-EA 104.7 ± 16.4 494.0 ± 101.1 *** 51.4 ± 7.5 140.1 ± 39.2 **
   ACC lesion 107.7 ± 11.5 854.1 ± 88.1 58.1 ± 7.9 205.3 ± 39.0
   ACC lesion + ipsi-EA 71.0 ± 10.5 395.9 ± 39.2 *** 65.1 ± 7.1 180.7 ± 45.9
   ACC lesion + contra-EA 91.3 ± 12.6 939.2 ± 92.6 61.7 ± 5.9 246.7 ± 56.3
  1. * p < 0.05; ** p < 0.01; *** p < 0.001, compared with the formalin group of the corresponding lesion type (sham lesion or ACC lesion). # p < 0.05, compared with the formalin + contralateral EA group of sham lesions.