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Table 1 Effects of ACC lesions on the anti-nociceptive effects of EA in rats with formalin injection

From: Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats

 

Paw lifting time (s)

Paw licking time (s)

 

Phase 1

Phase 2

Phase 1

Phase 2

Formalin to left paws

    

   Sham lesion

66.3 ± 13.9

595.5 ± 80.0

61.3 ± 12.2

440.1 ± 44.7

   Sham lesion + ipsi-EA

45.8 ± 8.0

282.7 ± 28.7 ***

56.1 ± 6.3

378.3 ± 48.2

   Sham lesion + contra-EA

65.3 ± 10.5

369.7 ± 59.8 **

47.0 ± 9.1

231.3 ± 30.6 ***

   ACC lesion

63.1 ± 8.1

623.6 ± 80.9

45.0 ± 8.2

362.6 ± 60.9

   ACC lesion + ipsi-EA

42.3 ± 6.4

401.7 ± 53.1 **

53.0 ± 5.4

357.9 ± 56.8

   ACC lesion + contra-EA

57.3 ± 3.2

496.9 ± 68.2

68.5 ± 9.2

358.8 ± 36.0#

Formalin to right paws

    

   Sham lesion

115.6 ± 19.2

815.5 ± 104.4

61.5 ± 4.7

269.6 ± 48.4

   Sham lesion + ipsi-EA

81.0 ± 11.9

365.1 ± 50.9 ***

63.0 ± 7.2

249.1 ± 42.7

   Sham lesion + contra-EA

104.7 ± 16.4

494.0 ± 101.1 ***

51.4 ± 7.5

140.1 ± 39.2 **

   ACC lesion

107.7 ± 11.5

854.1 ± 88.1

58.1 ± 7.9

205.3 ± 39.0

   ACC lesion + ipsi-EA

71.0 ± 10.5

395.9 ± 39.2 ***

65.1 ± 7.1

180.7 ± 45.9

   ACC lesion + contra-EA

91.3 ± 12.6

939.2 ± 92.6

61.7 ± 5.9

246.7 ± 56.3

  1. * p < 0.05; ** p < 0.01; *** p < 0.001, compared with the formalin group of the corresponding lesion type (sham lesion or ACC lesion). # p < 0.05, compared with the formalin + contralateral EA group of sham lesions.
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