Figure 8

Pain behavioral evaluation after DRG injections. The rate of hyperalgesic response to noxious punctate mechanical stimulation transiently increases for animals injected with vehicle (saline + polybrene 100 nM, n = 5), and is minimally affected by VSV-G pseudotyped first-generation lentivector (VSV-G LV1-EF1α-EGFP; n = 10). However, there is a persisting increase after injection of VSV-G pseudotyped second-generation lentivector (VAV-G LV2-EF1α-EGFP; n = 8), or RABPV pseudotyped second-generation lentivector (RABPV LV2-EF1α-EGFP; n = 5). Data are shown as mean ± SD. P < 0.05 for ANOVA interaction Group X Time.