Figure 9

Western blot analyses of CGRP levels in the DRG and spinal cord dorsal horn (SCDH) following chronic treatments with saline (NS), NG (a nNOS inhibitor, 75 μg), 7-NI (an nNOS inhibitor, 25 μg) and morphine (M, 10 μg) alone or in combination with NG (75 μg) or 7-NI (25 μg). A 7-day treatment with morphine increased CGRP levels in both the DRG and SCDH, effects inhibited by the co-administration of the nNOS inhibitors NG and 7-NI. *p < 0.01 vs respective saline group. #p < 0.01 vs respective morphine group.