Antidepressant-induced acute analgesic effects in ICS treated mice. Thermal pain threshold was assessed at P1 after control or ICS treatment, using the thermal paw withdrawal test. Results represent the time course of thermal paw withdrawal latencies (PWL, in seconds) after a single intrathecal injection of antidepressants. (A-D) Each data point in [control + vehicle] and [ICS + vehicle] groups is common. *p < 0.05, vs. vehicle-treated control group; #p < 0.05, vs. vehicle-treated and ICS-exposed groups. Data are expressed as the means ± S.E.M.; 4-8 mice per group.