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Table 1 Dose-dependent acute analgesic effects of antidepressants on ICS-induced thermal hyperalgesia

From: Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

Drug

Dose (μg)

n

AUC

Milnacipran

0.03

4

50.6 ± 21.5

 

0.1

6

281.9 ± 71.3*

 

0.3

4

166.2 ± 31.3*

Amitriptyline

5

3

51.1 ± 85.2

 

15

7

252.6 ± 42.2*

 

30

3

235.5 ± 64.4*

Mianserin

10

3

144.7 ± 171.5

 

20

4

527.8 ± 103.2*

Paroxetine

2

3

40.7 ± 62.4

 

5

7

211.2 ± 38.6*

 

10

3

251.3 ± 797*

  1. Thermal pain threshold was assessed at P1, using thermal paw withdrawal tests. Acute anti-hyperalgesic effects of milnacipran, amitriptyline, mianserin, and paroxetine were evaluated by AUC, as described in Materials and Methods. *p < 0.05, vs. vehicle-treated control group.
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Molecular Pain

ISSN: 1744-8069

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