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Table 1 Dose-dependent acute analgesic effects of antidepressants on ICS-induced thermal hyperalgesia

From: Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

Drug Dose (μg) n AUC
Milnacipran 0.03 4 50.6 ± 21.5
  0.1 6 281.9 ± 71.3*
  0.3 4 166.2 ± 31.3*
Amitriptyline 5 3 51.1 ± 85.2
  15 7 252.6 ± 42.2*
  30 3 235.5 ± 64.4*
Mianserin 10 3 144.7 ± 171.5
  20 4 527.8 ± 103.2*
Paroxetine 2 3 40.7 ± 62.4
  5 7 211.2 ± 38.6*
  10 3 251.3 ± 797*
  1. Thermal pain threshold was assessed at P1, using thermal paw withdrawal tests. Acute anti-hyperalgesic effects of milnacipran, amitriptyline, mianserin, and paroxetine were evaluated by AUC, as described in Materials and Methods. *p < 0.05, vs. vehicle-treated control group.