Table 2 Permanent relief from ICS-induced thermal hyperalgesia by repeated intrathecal (i.t.) administration of amitriptyline, mianserin or paroxetine

Control-vehicle

(i.t.)

8

9.84 ± 0.33

9.81 ± 0.45

10.24 ± 0.23

9.99 ± 0.22

ICS-vehicle

(i.t.)

8

10.22 ± 0.28

5.76 ± 0.15*

6.04 ± 0.16*

6.28 ± 0.21*

ICS- amitriptyline

(15 μg, i.t.)

4

10.48 ± 0.23

5.35 ± 0.36

8.44 ± 0.16#

9.35 ± 0.66#

ICS-mianserin

(20 μg, i.t.)

4

9.68 ± 0.30

5.35 ± 0.36

8.13 ± 0.25#

9.95 ± 0.66#

ICS- paroxetine

(5 μg, i.t.)

4

9.82 ± 0.44

5.47 ± 0.13

9.08 ± 0.46#

9.52 ± 0.21#