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Table 2 Permanent relief from ICS-induced thermal hyperalgesia by repeated intrathecal (i.t.) administration of amitriptyline, mianserin or paroxetine

From: Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

  n Pre
(sec)
P1
(sec)
P5
(sec)
P12
(sec)
Control-vehicle
(i.t.)
8 9.84 ± 0.33 9.81 ± 0.45 10.24 ± 0.23 9.99 ± 0.22
ICS-vehicle
(i.t.)
8 10.22 ± 0.28 5.76 ± 0.15* 6.04 ± 0.16* 6.28 ± 0.21*
ICS- amitriptyline
(15 μg, i.t.)
4 10.48 ± 0.23 5.35 ± 0.36 8.44 ± 0.16# 9.35 ± 0.66#
ICS-mianserin
(20 μg, i.t.)
4 9.68 ± 0.30 5.35 ± 0.36 8.13 ± 0.25# 9.95 ± 0.66#
ICS- paroxetine
(5 μg, i.t.)
4 9.82 ± 0.44 5.47 ± 0.13 9.08 ± 0.46# 9.52 ± 0.21#
  1. Antidepressants were administered between P1-P5, as described in Figure 3. Thermal pain threshold was assessed using the thermal paw withdrawal test. *p < 0.05, vs. vehicle-treated control group; #p < 0.05, vs. vehicle-treated and ICS-exposed groups.