Mechanical nociceptive stimulation evokes inhibitory responses in the PL/IL cortex of BLA → PL/IL (-) neurons. The figure shows different parameters of mechanical nociceptive stimulation-evoked inhibition, including the onset and duration of the inhibition, in sham and SNI rats treated for 7 days with vehicle (veh) or AA-5-HT (5 mg/kg, i.p.). "A", "B" and "C" show a representative ratemater record of a mechanical stimulus → PL/IL (-) neurons of sham/veh, SNI/veh and SNI/AA-5-HT rat, respectively. "D" and "E" show the onset and duration (mean ± SEM) of the inhibition, respectively, in the different groups of rats. * indicates statistically significant difference versus sham/veh and º versus SNI/veh. P < 0.05 was considered as value of significance and n = 10 was used for each group.