Figure 6From: Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain AMPK activators suppress hyperexcitability of sensory neurons. A) Patch clamp analysis of mouse primary sensory neurons cultured in the presence of NGF (50 ng/ml, n = 13) demonstrate an increase in the B) number of ramp currentevoked action potentials vs. vehicle (n = 14) and C) reduced latency to first action potential in response to ramp currents. Metformin (1 hr, n = 14) and A769662 (1 hr, n =12) reverse these parameters. A769662 effect persists after washout (n = 8). Colored stars denote significant effects compared to the NGF + Vehicle group. *p < 0.05, **p < 0.01 and ***p < 0.001.Back to article page