Skip to main content
Figure 3 | Molecular Pain

Figure 3

From: Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro

Figure 3

Lack of signal transducer gp130 reduced inflammation-induced mechanical hyperalgesia. (A) Unilateral hind-paw injection of CFA induced a drop of mechanical threshold after 6 h in both SNS-gp130-/- mice (black square, n = 8) and gp130fl/fl mice (open triangle, n = 8). SNS-gp130-/- mice showed attenuated mechanical hypersensitivity at all the time points tested after injection compared to gp130fl/fl mice (** p < 0.01, *** p < 0.001; ANOVA). (B, C) Similar degree of paw swelling in both mouse strains at 48 and 144 h after CFA injection (* p < 0.05, ** p < 0.01; Mann-Whitney U-test).

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us