Figure 1

Chemical, thermal and mechanical-induced pain and PSNL-induced tactile allodynia in PRIP-1^-/- mice and wild-type mice. (A) Duration of licking and biting responses for each 5-min interval after intraplantar injection of formalin in PRIP-1 ^-/-mice (n = 14) and wild-type mice (n = 10). Each point represents the mean and S.E.M. (*P < 0.05 vs. wild-type). (B) Hindpaw licking latency was measured at five temperatures (46, 48, 50, 52 and 55°C). Each value represents the mean and S.E.M. (n = 6-10). (C) Paw withdrawal threshold in response to tactile stimulation with von Frey filaments in PRIP-1 ^-/-mice (n = 6) and wild-type mice (n = 6). Each value represents the mean and S.E.M. (*P < 0.05 vs. contralateral side). (D) Paw withdrawal threshold in response to tactile stimulation with von Frey filaments in PRIP-1 ^-/-mice (n = 5-7) and wild-type mice (n = 8-14) before (0) and 3, 7 and 14 days after PSNL. Each point represents the mean and S.E.M. (*P <0.05, **P <0.01 vs. the contralateral side, n = 6-10).