Figure 1

Effects of MK-801 (A) and memantine (B) on oxaliplatin-induced mechanical allodynia in the von Frey test. Oxaliplatin (4 mg/kg) was administered i.p. twice a week for 4 weeks (Days 1, 2, 8, 9, 15, 16, 22 and 23). We confirmed the incidence of mechanical allodynia on Day 24. We carried out the drug evaluation on the next day. MK-801 (1-10 nmol/body) and memantine (0.1-1 μmol/body) were administered intrathecally. The von Frey test was performed immediately before (0 min) and at 30, 60, 90 and 120 min after administration. Values are expressed as mean ± SEM of 6-10 animals. ^†† P < 0.01 compared with vehicle, *P < 0.05 compared with oxaliplatin alone.