Changes in the NR2B protein (A, C) and mRNA (B, D) levels in the spinal cord in oxaliplatin-treated rats. Oxaliplatin (4 mg/kg) was administered i.p. twice a week for 1 (Days 1 and 2) or 4 weeks (Days 1, 2, 8, 9, 15, 16, 22 and 23). Western blot and PCR were performed to measure NR2B expression at the time points of Days 5 (A, B) and 25 (C, D) in the L4-6 spinal cord. Values are expressed as mean ± SEM of 6-9 animals. **P < 0.01 compared with vehicle.