Inflammatory heat hyperalgesia and mechanical allodynia are enhanced in Pap-/-
, Nt5e-/- and dKO mice. (A, B) WT, Pap-/-
, and dKO mice were tested for (A) thermal and (B) mechanical sensitivity before (BL) and following injection of CFA (arrow) into one hindpaw. The contralateral hindpaw served as control. All data are presented as means ± s.e.m. A repeated measures two-way ANOVA (P < 0.0005 for all genotypes) with Bonferroni's post-hoc test was used to compare WT to Pap-/-
, and dKO mice (n = 9-10 mice per group). *P < 0.05; **P < 0.005, ***P < 0.0005. There were no significant differences between dKO and Pap-/- or dKO and Nt5e-/- mice.