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Table 1 Summary of adenosine transient events in spinal cord lamina II.

From: PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

Genotype [Ca 2+ ] (mM) [Ado] peak (nM) Frequency (events/min) Transient Time (s) #
WT (n = 19) 2.5 570 ± 50 0.35 ± 0.04 1.5 ± 0.1
WT (n = 5) 0.0 410 ± 50 0.06 ± 0.03** 1.8 ± 0.3
Pap-/- (n = 10) 2.5 690 ± 150 0.14 ± 0.04* 1.5 ± 0.1
Nt5e-/- (n = 10) 2.5 360 ± 20 0.14 ± 0.07* 1.5 ± 0.1
dKO (n = 16) 2.5 380 ± 40 0.10 ± 0.03** 1.2 ± 0.1
  1. Statistics: One-way ANOVA (P < 0.05) followed by Newman-Keuls multiple comparison post-hoc test to compare all genotypes relative to WT (2.5 mM Ca2+); *P < 0.05, **P < 0.005, ***P < 0.0005.
  2. # Transient time was measured from the onset of the transient until the signal decayed to baseline.