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Table 1 Summary of adenosine transient events in spinal cord lamina II.

From: PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

Genotype

[Ca 2+ ] (mM)

[Ado] peak (nM)

Frequency (events/min)

Transient Time (s) #

WT (n = 19)

2.5

570 ± 50

0.35 ± 0.04

1.5 ± 0.1

WT (n = 5)

0.0

410 ± 50

0.06 ± 0.03**

1.8 ± 0.3

Pap-/- (n = 10)

2.5

690 ± 150

0.14 ± 0.04*

1.5 ± 0.1

Nt5e-/- (n = 10)

2.5

360 ± 20

0.14 ± 0.07*

1.5 ± 0.1

dKO (n = 16)

2.5

380 ± 40

0.10 ± 0.03**

1.2 ± 0.1

  1. Statistics: One-way ANOVA (P < 0.05) followed by Newman-Keuls multiple comparison post-hoc test to compare all genotypes relative to WT (2.5 mM Ca2+); *P < 0.05, **P < 0.005, ***P < 0.0005.
  2. # Transient time was measured from the onset of the transient until the signal decayed to baseline.
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Molecular Pain

ISSN: 1744-8069

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