Skip to main content

Table 2 Acute mechanical and thermal sensitivity

From: PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

Behavioral Assay

WT

Pap -/-

Nt5e -/-

dKO

 

Withdrawal threshold:

Electronic von Frey

7.8 ± 0.3 g

7.8 ± 0.4 g

8.0 ± 0.2 g

8.0 ± 0.2 g

 

Withdrawal latency:

Radiant heating of hindpaw (Hargreaves Method)

9.9 ± 0.4 s

10.2 ± 0.4 s

10.6 ± 0.4 s

10.2 ± 0.4 s

Tail immersion at 46.5°C

16.9 ± 1.2 s

14.3 ± 0.7 s

12.6 ± 0.6 s**

13.1 ± 1.0 s*

Tail immersion at 49.0°C

7.2 ± 0.7 s

4.7 ± 0.2 s***

4.0 ± 0.2 s***

4.7 ± 0.3 s**

Hot plate at 52°C

33.5 ± 1.7 s

37.7 ± 2.6 s

29.6 ± 1.5 s

31.1 ± 2.2 s

Hot plate at 55°C

16.2 ± 1.1 s

13.5 ± 0.5 s

13.5 ± 1.1 s

12.7 ± 0.8 s*

  1. Data are expressed as means ± s.e.m. One-way ANOVAs were performed with Bonferroni's post hoc test to compare each genotype to WT. For post hoc tests, *P < 0.05, **P < 0.005, ***P < 0.0005. n = 10 male mice tested per genotype.