From: PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine
Behavioral Assay | WT | Pap -/- | Nt5e -/- | dKO |
---|---|---|---|---|
 | Withdrawal threshold: | |||
Electronic von Frey | 7.8 ± 0.3 g | 7.8 ± 0.4 g | 8.0 ± 0.2 g | 8.0 ± 0.2 g |
 | Withdrawal latency: | |||
Radiant heating of hindpaw (Hargreaves Method) | 9.9 ± 0.4 s | 10.2 ± 0.4 s | 10.6 ± 0.4 s | 10.2 ± 0.4 s |
Tail immersion at 46.5°C | 16.9 ± 1.2 s | 14.3 ± 0.7 s | 12.6 ± 0.6 s** | 13.1 ± 1.0 s* |
Tail immersion at 49.0°C | 7.2 ± 0.7 s | 4.7 ± 0.2 s*** | 4.0 ± 0.2 s*** | 4.7 ± 0.3 s** |
Hot plate at 52°C | 33.5 ± 1.7 s | 37.7 ± 2.6 s | 29.6 ± 1.5 s | 31.1 ± 2.2 s |
Hot plate at 55°C | 16.2 ± 1.1 s | 13.5 ± 0.5 s | 13.5 ± 1.1 s | 12.7 ± 0.8 s* |