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Figure 5 | Molecular Pain

Figure 5

From: EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat

Figure 5

The effects of intra-VL PAG microinjections of vehicle (0.05% DMSO in ACSF), ONO-DI-004 (0.001, 0.01 and 0.1 pg) alone, or ONO-DI-004 (0.1 pg) in combination with L355677 (0.1 pg) (A and B) or L355677 (0.1, 1 and 10 pg) (C and D), on the spontaneous firing of RVM ON (A and C) or OFF (B and D) cells. Vehicle or drugs were administered at time 0, whereas L 335677 (0.1 pg) was administered 10 min beforehand (A and B). Each point represents the mean ± S.E.M of 6-7 neurons. * indicates a statistically significant difference vs vehicle and° versus ONO-DI-004 (0.1 pg). P values < 0.05 were considered statistically significant.

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