Normal cutaneous pain sensitivity in transgenic mice to thermal and inflammatory stimulation. A-B. Comparison of thermal sensitivity in wild type (WT) and transgenic mice (Tg) by cutaneous application of thermal stimulation. No significant difference was detected between the two groups in tail withdrawal test (A) at 47°C and 49°C and in hot plate test (B) at 53°C (mean ± s.e.m, n = 7-11). C. The Tg mice displayed equivalent licking/biting behavior in both the acute and tonic phases in 5% formalin test (mean ± s.e.m, n = 7-9). The acute phase of the formalin test was defined as 0-10 min after injection and the tonic phase as 10-60 min after injection.