Figure 4

Nimesulide attenuates established allodynia in MIA-treated rats. A: Timecourse of the effects of repeated oral administration of nimesulide (10 mg.kg^-1; days 14-20) or vehicle on mechanical withdrawal thresholds of the ipsilateral hindpaw in MIA and saline-treated rats. Arrows indicate the timing of drug administration. B: Histograms comparing the effects of repeated oral administration of nimesulide before (day 14), during (day 18) and after (day 21 and 28) drug administration. Data are expressed as mean ± SEM. Statistical analyses were performed using a Kruskall-Wallis test with a Dunn's post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.001.