Figure 3

Steady-state inactivation curves obtained from Cav3.2 channels before and after application of 10 μM NMP-4 (A), NMP-7 (B) or NMP-144 (C). The half-inactivation potentials before and after the treatment with drugs were as follows: NMP-4 -52.9 ± 1.4 mV and -72.9 ± 4.7 mV (n = 4, P < 0.01, paired t test); NMP-7: -50.5 ± 0.6 mV and -63.3 ± 3.5 mV (n = 4, P < 0.05, paired t test); NMP-144: -53.7 ± 1.6 mV and -55.8 ± 2.2 mV (n = 4, P > 0.05, paired t test).