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Table 1 Neurobiotin labeling of VGluT2-IR and CGRP-IR terminals in lamina I

From: Non-peptidergic small diameter primary afferents expressing VGluT2 project to lamina I of mouse spinal dorsal horn

  Medial Mid Lateral Overall
Neurobiotin-labeled terminals with CGRP-IR as proportion of volume of total CGRP-IR terminals 37 ± 10% 53 ± 7% 42 ± 6% 44 ± 4%
Neurobiotin-labeled terminals with VGluT2-IR as proportion of volume of total VGluT2-IR terminals 26 ± 10% 39 ± 10% 13 ± 4%* 26 ± 4%
Neurobiotin-labeled VGluT2-IR terminals as proportion of Neurobiotin-labeled CGRP-IR terminals 69 ± 12% 70 ± 9% 28 ± 7%* 56 ± 4%
  1. The proportion of VGluT2-IR terminals which were labeled with Neurobiotin as well as the ratio of Neurobiotin-labeled VGluT2-IR terminals compared to Neurobiotin-labeled CGRP terminals were significantly lower in lateral lamina I compared to medial and mid lamina I (two-way ANOVA with Bonferroni corrections using 95% confidence limits; p < 0.05, indicated by asterisks). Analysis of L3 spinal cord sections, n = 6 animals.