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Figure 3 | Molecular Pain

Figure 3

From: Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)

Figure 3

Histamine and PAR-2-induced hyper scratching in PI3Kγ deficient mice. (A and B) The total number of scratches that occurred over a 40-minute time period after histamine injection were counted. PI3Kγ KO exhibited enhanced scratching compared to WT littermates. (C and D) PAR-2 agonist induced itch was recorded; scratches were counted for 30 minutes. (E and F) The PI3Kγ KO scratched vigorously for the first 5 minutes; the latency until the first scratch was significantly earlier than in WT mice.

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