Table 1 Recent itch studies using genetically engineered mice
From: Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)
Deleted gene | Pruritogens | Scratching | Reference |
|---|---|---|---|
PLCβ3 | Histamine, HTMT, Compound 48/80, Clobenpropit | Reduced | Neuron (2006) |
GRPR | Compound 48/80, PAR-2, chloroquine | Reduced | Nature (2007) |
VGLUT2 (Spinal cord specific) | PAR-2, 5-HT, Chloroquine, Compound 48/80, Capsaicin | Increased | Neuron (2010) |
Bhlhb5 | Histamine, Compound 48/80 PAR-2, 5-HT, Chloroquine | Increased | Neuron (2010) |
TLR7 | 5-HT, ET-1, PAR-2, Chloroquine | Reduced | Nature Neuroscience (2010) |
TRPA1 | Chloroquine, BAM8-22 | Reduced | Nature Neuroscience (2011) |
PI3Kγ | istamine, PAR-2 | Increased | The present study |