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Figure 2 | Molecular Pain

Figure 2

From: Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway

Figure 2

The nNOS/nitric oxide pathway participates in the peripheral antinociceptive effect of a KOR agonist. (A) Mechanical hyperalgesia in mice was induced by an ipl. injection of PGE2 (30 ng/paw). The antinociceptive effect of a local injection of U50488 (3 μg/paw, 30 min after PGE2 injection) after PGE2-induced hyperalgesia was prevented by treatment with a non-selective inhibitor of NOS (L-NMMA, 10 mg/kg, s.c., 30 min before the U50488 injection) (B) Mechanical hyperalgesia in rats was induced by an ipl. injection of PGE2 (100 ng/paw). The antinociceptive effect of U50488 treatment at a locally effective dose (10 μg/paw, 2 h after PGE2 injection) after PGE2-induced hyperalgesia was prevented by treatment with a selective inhibitor of nNOS (N-propyl-L-arginine, 30 μg/paw, 30 min before U50488 injection). Data are expressed as the mean ± S.E.M. of 5-6 animals per group. * Indicates statistical significance compared to the vehicle group. # Indicates statistical significance compared to the U50488 treated group. P < 0.05, one-way ANOVA, followed by the Bonferroni correction.

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Molecular Pain

ISSN: 1744-8069

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