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Figure 7 | Molecular Pain

Figure 7

From: Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root

Figure 7

Effects of progesterone treatment (16 mg/kg/day) upon PMP22 expression. (A) Vehicle treatments did not affect the LPA-induced decreases in PMP22 expression in the trigeminal nerve root compared with naïve rats on postoperative day 5. However, decreased PMP22 expression, produced by LPA injection, was recovered following treatment with progesterone. (B) Western blot analysis also showed that LPA suppresses the 19 kDa band for PMP22, which was recovered by treatment with progesterone. GAPDH was used as a loading control. (C) Quantitative analyses of western blotting data. * P < 0.05, naive- vs. LPA/vehicle-treated group. # P < 0.05, LPA/vehicle-treated group vs. LAP/progesterone-treated group. Scale bar, 50 μm.

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