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Figure 7 | Molecular Pain

Figure 7

From: Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9

Figure 7

Intrathecal injections of IL-1β siRNA prolong morphine analgesia and reduce IL-1β expression in DRGs. (A) Acute morphine-induced analgesia is prolonged after intrathecal injections of IL-1β siRNA (3 μg, 24 and 2 h prior to morphine injection). Morphine analgesia was tested at 1 h and 2 h after the morphine injection (10 mg/kg, s.c.). *P < 0.05, compared to non-targeting control (CTRL) siRNA, Two-Way ANOVA followed by Bonferroni post hoc test, n = 6 mice. (B, C) Western blotting analysis showing IL-1β expression (17 kDa) in DRGs (B) and spinal cord dorsal horns (C) after intrathecal injections of IL-1β siRNA (siRNA) or control siRNA. *P < 0.05, compared to control, Mann-Whitney test, n = 6 mice.

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Molecular Pain

ISSN: 1744-8069

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