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Figure 1 | Molecular Pain

Figure 1

From: Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice

Figure 1

Subcutaneous morphine increases MMP-9 expression and activity in DRGs. (A) Western blotting showing the time course of MMP-9 expression in lumbar DRGs after morphine (s.c., 10 mg/kg). (B) Gelatin zymography showing the time course of MMP-9 activity in lumbar DRGs after morphine. Note that MMP-2 activity remains unchanged after morphine injection. (C) Western blotting showing the time course of MMP-9 expression in lumbar spinal cord dorsal horns after morphine (s.c., 10 mg/kg). Note that subcutaneous morphine only induces MMP-9 expression in DRGs but not spinal cords. *P < 0.05, compared to naive control, ANOVA followed by Bonferroni post hoc test, n = 4 mice.

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Molecular Pain

ISSN: 1744-8069

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