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Figure 1 | Molecular Pain

Figure 1

From: Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K2P) and voltage-gated (Kv1.1 and Kv1.2) potassium channels

Figure 1

Effects of IQ on AP duration and membrane resistance of DRG neurons in WT and TLR7 KO mice. A. Representative trace of AP of DRG neuron from WT and TLR7 KO before and after application of IQ. Bar graph indicates the average of AP duration of DRG neurons with or without IQ treatment from WT and TLR7 KO mice. B. Left column shows the representative example of change of membrane resistance induced by injection of negative current. Average effect of IQ on membrane resistance compared with WT and KO is shown as bar graph. Protocol for AP induction and membrane resistance by current injection was shown in bottom of traces of A and C. The number in each bar indicates the number of neurons. Error bars indicate S.E.M. (**, P > 0.01).

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