The selective mGluR5 antagonist, fenobam, is analgesic in distention-induced bladder pain model. A. Treatment with the vehicle used to dissolve fenobam (100% DMSO) has no effect on the response to bladder distention. B. Treatment with an mGluR5 antagonist, fenobam, is analgesic in a bladder distention-evoked pain model. C&D. Fenobam and DMSO reduce the evoked response in mGluR5 KO mice. +/- SEM,* p < 0.05, **p < 0.01, ***p < 0.001. 2-way ANOVA with Bonferroni post-hoc test.